Our analyses suggest that some metabolic reactions may be conserved despite the loss of canonical eukaryotic enzymes, like the sterol side-chain reductase (SSR). Our findings are consistent with the ...

Sterols are also known as steroid alcohols, an example of which is cholesterol. They are generated in living systems from acetyl-coA by the HMG-CoA reductase pathway. Xu, Meng, St-Germain et al.

Endogenous intracellular allosteric modulators of GPCRs remain largely unexplored, with limited binding and phenotype data available. This gap arises from the lack of robust computational methods for ...

In this study, through joint enriched pathway analysis of differentially abundant lipid metabolites and differentially expressed genes, we found that GPL metabolism, AA metabolism, linolenic acid ...

Furthermore, we discovered that Scu treatment reversed some of the differences in MASLD metabolic pathways through KEGG enrichment analysis. Compared with the control group, genes upregulated in the ...

Phase-pure samples of a metastable allotrope of silicon, Si-III or BC8, were synthesized by direct elemental transformation at 14 GPa and similar to 900 K and also at significantly reduced pressure in ...

School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu Province 210094, PR China ...