SLC25A1 drives citrate export from the mitochondria to the cytosol, where it fuels acetyl-CoA synthesis by ATP citrate lyase (ACLY). This acetyl-CoA supply sustains FSP1 acetylation and prevents its ...

(Waltham, MA). The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) primary antibodies were purchased from Abcam (Cambridge, U.K.). Acetyl-CoA carboxylase (ACC) and phosphorylated ACC (p-ACC) were ...

Some commonly prescribed drugs, such as trazodone and aripiprazole, have been found to inhibit sterol biosynthesis, leading to increased levels of 7-DHC and decreased cholesterol levels in the brain.

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

Many reports have revealed that intestinal flora plays a crucial role for the occurrence and development of MASLD, through mechanisms such as flora translocation, endogenous ethanol production, ...

decrease VLDL production/secretion and increase VLDL metabolism by: decreasing lipogenesis by decreasing the enzymatic conversion of acetyl CoA to FAs; increasing ß-oxidation of FA; inhibiting ...

Although we demonstrated that elocalcitol upregulates miR-146a expression and that its deletion diminishes the therapeutic effects of elocalcitol, the precise molecular mechanisms by which miR-146a ...

suggesting that diabetes modulates cholesterol metabolism more than obesity alone. To this end, we studied cholesterol absorption efficiency and sterol balance in obese subjects with and without ...

From the GO analysis, we screened the upregulated differentially expressed genes and identified key pathways, including mitophagy, autophagy, ferroptosis, apoptosis, nonalcoholic fatty liver disease ...