Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

First Mouse With Two Male Parents to Reach Adulthood Jan. 28, 2025 — A team of stem cell scientists have successfully used embryonic stem cell engineering to create a bi-paternal mouse -- a ...

The authors examine the role of Numb, a Notch inhibitor, in intestinal stem cell self-renewal in Drosophila during homeostasis and regeneration. This is an important study providing evidence of a Numb ...

Background: We showed that intestinal epithelial stem cells (IESCs) obtained from healthy young donor rats and transplanted to aging animals after stroke reduced infarct volume and sensorimotor ...

When we developed the ability to convert various cells into a stem cell, it held the promise of an entirely new type of therapy. Rather than getting the body to try to fix itself with its cells or ...

Based on RNAi combinations and double mutant clonal analyses, they propose that Numb has a function in inhibiting Notch pathway to maintain intestinal stem cells, and is a backup mechanism with BMP ...

M cells are highly specialised cells present within the epithelium overlying organised lymphoid follicles of the small and large intestine. They play a central role in the initiation of mucosal immune ...

Maternal microbiome-derived metabolites during pregnancy impact offspring stem cell function, offering potential therapeutic targets to improve child health.

Enteropathy-associated T-cell lymphoma (EATL) is a type of lymphoma that directly targets the lining of the small intestine and occasionally the large intestine. EATL is frequently seen in people with ...