‡ Department of Biophysics and Chemical Biology/Bio-MAX Institute, Seoul National University, Seoul, Korea § Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, ...

Matrix metalloproteinase-7 (MMP-7) was confirmed to have significant value in the diagnosis of biliary atresia. However, so far, the reference range and its cut-off value for diagnosing biliary ...

We highlight inflammation-driven injury mechanisms in stroke, including oxidative stress, increased MMP (matrix metalloproteinase) production, microglial activation, and infiltration of peripheral ...

Additionally, ECM1 binds to mature MMP-2 and MMP-9 and thereby inhibits their proteolytic activity, thus reducing LAP degradation and LTGF-β1 activation. In vivo, KTFR peptide exerts an effect similar ...

New findings show that the homeostatic levels of circulating sphingosine-1-phosphate (S1P) are mainly determined by the secretion from erythocytes (blood) and probably from endothelial cells ...

针对慢性难愈性伤口（CRW）中细胞外基质（ECM）失衡的难题，空军军医大学唐都医院烧伤整形科团队通过构建深度学习（DL）模型，首次实现了机械拉伸参数（频率、强度、时长）对成纤维细胞基质金属蛋白酶-2（MMP-2）基因表达的精准预测。模型训练集R2 达0.73 ...

为解决鲸类动物如何通过分子进化适应深海潜水生理挑战的问题，南京师范大学的研究团队开展了针对基质金属蛋白酶(MMP)基因家族的系统研究。通过比较基因组学、蛋白质功能验证等技术，发现鲸类MMP9基因存在特异性N319S突变，导致胶原降解能力减弱而迁移 ...

Blood-brain barrier (BBB) dysfunction contributes to the pathogenesis of cerebral small vessel disease. This study assessed SEW2871, a selective agonist of sphingosine-1-phosphate receptor 1, as a ...

Background: Several matrix metalloproteinases (MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). In mice, MMP-12 plays a crucial role in the development of ...

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Degenerative orthopedic diseases, as a global public health problem, ...

Analysis of the structure suggests ways to design inhibitors with improved SPHK1 or SPHK2 selectivity, as well as ways to take advantage of SPHK features that might allow improved inhibitor ...

On Monday, Engine 9-1 and Tanker 9 from the MMP&W Volunteer Fire Company responded to a house fire on Drapper Road in Washington County. At the time of dispatch, Engine 9-1 was participating in a ...