We validated several tumor-specific antigens using targeted mass spectrometry, peptide-HLA refolding and ribosome profiling. For example, we demonstrate that antigens derived from alternatively ...

However, its application to solid tumors remains constrained by antigen heterogeneity and on-target, off-tumor toxicities. One critical emerging approach to combat this challenge is logic-gated ...

Historically, the vast majority of pharmaceutical drugs have been meticulously designed down to the atomic level. The ...

A scientific revolution is underway as researchers push to bring atomic-level precision, once reserved for small molecule ...

Biotech firms are engineering smarter, safer gene delivery systems to enhance the safety and efficacy of genetic medicines.

Historically, small molecule drugs have been precisely designed down to the atomic scale. Considering their relatively large complex structures, nanomedicines have lagged behind. Researchers argue ...

Prostate specific membrane antigen (PSMA) expression is prevalent in prostate cancer, preserved during malignant transformation, and increases in response to anti-androgen therapies, making it a ...

Given that only a small fraction of patients with cancer exhibits specific markers making them eligible for effective ...

Single-cell RNA sequencing (scRNA-seq) has confirmed that MM exhibits high intra-tumor heterogeneity, comprising a mixture of ...