G) Heatmap of fold change expression of soluble ligands secreted by IPAH PAAF compared to donor PAAF (n=4 for each condition). H) Gene expression changes of contractile markers smooth muscle myosin ...

Smooth muscle myosin heavy chain: MHY11. Friedman test followed by Dunn’s multiple comparisons test (*p<0.05). The divergent fates and distinct disease states that cells acquire, can be traced to ...

Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life ...

A pulled or strained abdominal muscle — which some people call the stomach muscle — can occur during exercise, heavy lifting, and other activities. Ice packs, stretches, and pain relief ...

When stimulated by the autonomic nervous system to contract from the release of hormones or other chemical signals, smooth muscle cells shorten via the movement of actin and myosin myofilaments.

We differentiated induced pluripotent stem cells from risk, nonrisk donors at 9p21.3, and isogenic knockouts into vascular smooth muscle cells (VSMCs). We performed single-cell transcriptomic ...

A team has discovered a possible therapeutic approach to repair injured muscles either from aging or degenerative muscle disorders. For millions of people, losing muscle isn't just about weakness ...

EPI-321, the startup’s lead program, uses CRISPR tools to stop errant expression of a gene implicated in the muscle-wasting condition. Epicrispr will start a Phase 1 trial this year in New Zealand, ...

The kinetic cycle of myosin-driven movement consists of four ... has been the favourite model used to explain how muscles contract and how non-muscle myosins function. However, since Huxley ...

Wild type OreR and UNC45 knockdown Drosophila melanogaster somatic larva body wall muscles are used to elucidate the influence of myosin organization on SHG imaging response. Structural changes due to ...

For asthma experiments, Bronchial Smooth Muscle Cells (BSMCs) from non-asthmatic (n=3) and asthmatic (n=4) subjects were purchased from a commercial source (Lonza, MD, United States). These cells were ...