Compared to CD38 antibodies, small-molecule inhibitor offer advantages, including better tissue penetration, oral bioavailability, and cost-effectiveness. CD38 inhibition may restore NAD levels, ...

This makes TG2 a promising target for treatment. We previously identified MT4 as a promising small molecule inhibitor (SMI) able to disrupt TG2-FN protein-protein interaction, prevent cancer cell ...

This evolving landscape is tightening its grip on an industry already struggling to keep pace with patient demand, and small molecule drug developers are feeling the pinch most acutely.

Koch Institute for Integrative Cancer Research, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States The Broad Institute of ...

Cancer Research Horizons, CRUK Scotland Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, U.K.

In chemical biology, this term also covers metal ions and in this discipline small molecules may play the role of a chemical tool. The identification of a small molecule selectively targeting the ...

The three platform deals are long-term bets, but broaden Genentech’s drug discovery capabilities, particularly in small-molecule R&D. The Convelo deal focuses on the development of novel drug ...

Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, China; Department of Molecular, Cellular, ...

Left to Right: Ethan Grimes, BS, and Paul Morgan, MD, conduct rational drug design at the newly launched AI Small Molecule Drug Discovery Center at the Icahn School of Medicine at Mount Sinai.

“Today’s two presentations highlight the unique potential of VG-3927 as an orally bioavailable, highly potent and CNS penetrant small molecule TREM2 agonist and provide the complete dataset ...