The collapse of DNA replication forks leads to the formation of single-ended DNA double-strand breaks. One would have assumed that these breaks would be repaired as soon as possible.

Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA ...

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological ...

Double-strand breaks are among the most difficult forms of DNA damage for cells to repair because they disrupt the continuity of DNA and leave no intact template to base new strands on.

引言在与白血病等恶性肿瘤的斗争中，阿糖胞苷 (cytarabine) 是一款功勋卓著的化疗药物，自上世纪60年代以来，它拯救了无数生命，至今仍是急性髓系白血病 (acute myeloid leukaemia, AML) ...

We spoke with the developers and manufacturers of the CRISPR gene therapy used to treat KJ Muldoon’s rare genetic condition, ...