The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking ... activated signalling pathways in human cancer. Oncogenic activation of this pathway commonly ...

Resistant cancer cells exhibit traits like drug efflux, enhanced DNA repair, protein homeostasis, and an immunosuppressive ...

Despite major interest in this pathway for cancer drug discovery ... for other purposes either directly or indirectly target PI3K signaling, such as the rapamycin analogs, the ether lipids ...

Pat Gulhati, MD, PhD, discusses findings from a comprehensive analysis of genetic, immunological, and signaling pathway variations in pancreatic cancer.

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

is a leading cause of cancer-related deaths worldwide. The complexity of its pathogenesis, involving genetic mutations, dysregulated signaling pathways, and compromised immune surveillance ...

"Our results establish an outside-in signaling mechanism that provides ... could help design drugs that exploit this pathway to find and destroy cancer cells. More information: Bin Xie et al ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

Purine nucleotides are essential for cell growth and function as they serve as nucleic acid building blocks, signaling molecules ... they determined the cells’ dependence on each pathway. Although the ...

Lutris Pharma, a clinical stage biopharmaceutical company focused on improving anti-cancer therapies by reducing cutaneous ...