S100A4 is a Ca 2+-binding protein involved in multiple chronic inflammatory and neoplastic conditions. This review focuses on recent advances in the understanding of S100A4 function in immune cells, ...

站在转化医学的十字路口，这项研究带来的启示远超实验数据本身。首先，它验证了表观遗传调控在抗癌药物开发中的战略地位；其次，揭示了多靶点协同作用的可能性；更重要的是为中药现代化提供了分子层面的理论支撑。对于药企研发部门，建议优先布局三重方向：建立标准化提取工艺、探索与现有化疗方案的协同效应、开发靶向递送系统。监管部门则需要加快建立天然抗癌成分的质量控制体系，而临床机构应当着手设计早期临床试验方案。

在现代医学研究中，关于人参皂苷Rg3对胃癌的影响，尤其是针对BGC-823胃癌细胞株的研究引起了广泛关注。最近，高川与张明亮在《浙江医学》上发表了一篇研究，探讨了这一天然化合物在人胃癌细胞生长及凋亡过程中的潜在作用。 研究的重点在于人参皂苷Rg3的 ...

《自然·方法》的研究给出颠覆性答案：研究团队开发的Spotiphy，通过人工智能算法成功突破技术壁垒。这项技术不仅能以单细胞精度绘制全基因组表达图谱，更惊人的是——它让显微镜下那些未被传统ST技术捕获的"空白区域"细胞集体"显形"。在小鼠阿尔茨海默病 ...

Calluna’s most advanced programmes are CAL101, an anti-S100A4 antibody in phase 1 with potential to treat idiopathic pulmonary fibrosis, chronic kidney disease, systematic sclerosis, rheumatoid ...

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Objectives This study aimed to identify plasma proteomic signatures that differentiate active and inactive giant cell arteritis (GCA) from non-disease controls. By comprehensively profiling the plasma ...

Rheumatoid arthritis (RA) is an autoimmune disorder characterized by inflammation and bone erosion. The exact mechanism of RA is still unknown, but various immune cytokines, signaling pathways and ...

Centre for 3D models of Health and Disease, Division of Surgery and Interventional Science, University College London, London W1W 7TY, U.K. Centre for 3D models of Health and Disease, Division of ...