Ribavirin, the nucleoside ... In the enzymatic method, purine nucleoside phosphorylase is used to catalyze ribavirin synthesis from its precursors – purine nucleoside and 2H-1,2,4-triazole-3 ...

A new finding from Poland is the association between serum prohepcidin and PEG-IFN/ribavirin efficacy in chronic hepatitis C, which may suggest possible HCV interference with hepcidin synthesis.

Researchers at Penn State have discovered a new mechanism for an existing antiviral drug that could permit the design and production of a new class of antiviral agents to treat RNA viruses.

To determine the effect of incorporated ribavirin on subsequent rounds of RNA synthesis, we evaluated the kinetics of CMP and UMP incorporation into sym/sub-R, a template containing ribavirin ...

The currently recommended regimen for the treatment of chronic hepatitis C is the combination of weekly subcutaneous injections of peginterferon and twice daily oral doses of ribavirin . 13,28,29 ...

Clinical pharmacology. Ribavirin is a purine nucleoside analogue. Although its mechanism of action is still debated, it prevents replication of a large number of RNA and DNA viruses by inhibiting the ...

Nature - Mechanism of action of interferon and ribavirin in treatment of hepatitis C. ... (PKR), which blocks viral protein synthesis through inhibition of eukaryotic initiation factor 2 (eIF2).

Sofosbuvir is an oral nucleotide analogue inhibitor of the HCV NS5B polymerase that is effective against HCV genotypes 2 and 3 when it is administered in combination with ribavirin. 13,14 In phase ...

Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a purine analogue and a commonly used antiviral agent against both RNA and DNA viruses. With up to five suggested mechanisms of ...