But other operons respond to the presence of their small molecule signal ligand; that is, they are negatively regulated by a repressor protein, but they are inducible (i.e., they can be turned on ...

Inhibitors such as the tetracycline (tet) repressor or small interfering RNAs have a certain degree of leakiness, which make them unsuitable as sole regulators for tight switches. So Collins and ...

Learn about our Editorial Policies. LacI is a tetrameric protein, using two dimers to bind two specific, identical DNA sequences. This specificity narrows the ability to use the LacI system in cases ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain ...