The center section of the diagram gives values for the difference in rates of sodium and potassium excretion between the control and first day of drug administration. Urinary osmolal concentration ...

The renal excretion of digitoxin was studied in cardiac patients who were (1) decompensated and (2) compensated. It was found that the renal excretion of digitoxin was not changed in patients ...

The presented kidney model can be implemented into whole body physiologically based pharmacokinetic models and extended in order to simulate the renal excretion of lipophilic drugs which may also ...

will accelerate the renal excretion of drug in patients with barbiturate intoxication. 1–5 When the intoxication is due to a long acting barbiturate — for example, phenobarbital — urinary ...

In contrast, polar compounds, such as most drug metabolites, are not able to diffuse back into the circulation so easily, and are excreted from the body in the urine. The renal excretion of drugs ...

Abstract: Urinary excretion of type IV collagen (Col4), a component of glomerular and tubular basement membrane and mesangial matrix, is considered to be a promising marker of kidney fibrosis. This ...

It is primarily eliminated renally by glomerular filtration and renal tubular secretion. To evaluate the roles of renal uptake and efflux transporters in the excretion of meropenem and potential drug ...

If pressure natriuresis is to play an important role in arterial pressure control, renal perfusion pressure must have a long-term effect on urinary sodium excretion. The aim of this study was to ...

Department of Drug Metabolism and Pharmacokinetics, Genentech, 1 DNA Way, South San Francisco, California 94080, United States, ...