The center section of the diagram gives values for the difference in rates of sodium and potassium excretion between the control and first day of drug administration. Urinary osmolal concentration ...

In contrast, 5 weeks of a high-fat diet in the bilaterally renal-denervated group did not significantly increase arterial pressure (which went from 87±3 to 90±4 mm Hg). Furthermore, the decrease in ...

Today, a brief rundown of news involving Sarepta Therapeutics, Novartis and Allakos, as well as updates from CSL Behring and Roche that you may have missed.

Department of Biological Sciences, The University of Texas at Dallas, United States; Department of Urology, University of Texas Southwestern Medical Center, United States; ...

and Alloy Therapeutics Inc. have signed a memorandum of understanding to jointly discover and develop first-in-class renal tissue-targeting drugs. Precision medicines for chronic renal conditions ...

Phase 3 results showed Empaveli reduced proteinuria by 68% and stabilized kidney function (p=0.03 ... Sales Timing For Syfovre The Prescription Drug User Fee Act (PDUFA) target action date ...

of each drug at intervals of one month apart ... Patients with varying degrees of renal impairment were given similar injections and bled at intervals spaced to permit delineation of disappearance ...

How does the urinary system work? The urinary system's function is to filter blood and create urine as a waste by-product. The organs of the urinary system include the kidneys, renal pelvis, ureters, ...

The hypothalamic-pituitary-adrenal axis (HPA) regulates cortisol synthesis and release, 11β-hydroxysteroid dehydrogenase enzymes mediate metabolic interconversion between active and inactive forms, ...

Overall, AKI and CKD represent kidney failure at different time phases. However, currently, no clinically targeted, highly effective, and with low toxicity drug and/or treatment are available for AKI ...

Sixty-six percent total renal excretion: 36% unchanged, 30% inactivated metabolites. CrCl ≥60 mL/min, CKD stages I–II. CrCl 30–60 mL/min, CKD stage III. CrCl 15–30 mL/min, CKD stage IV. For CrCl ≤15 ...