Pregabalin does not bind to plasma proteins. Pregabalin is eliminated primarily by renal excretion as an unchanged drug and has an elimination half-life of approximately 6 h. [14] For patients ...

Excretion of over 95% of ... pharmacodynamic properties of a parent drug and its active or inactive metabolites are greatly affected in patients with kidney disease and its resulting uremia.

Renal function, measured by creatinine clearance, phenolsulfonphthalein excretion and concentrating ability, continued to improve gradually. Asymptomatic hypertension and albuminuria were still ...

Buying Regulus ties neatly into Novartis' push into kidney disease therapies, with a portfolio that includes a trio of drugs to treat IgA nephropathy (IgAN) – two of which are already FDA ...

AstraZeneca has licensed in an antisense drug from Ionis Pharmaceuticals to treat kidney disease in a deal worth up to $330 million. Antisense drugs contain non-coding strands of mRNA that block ...

doctors.org.uk Objective 30 mm Hg drops in office systolic blood pressure are reported in trials of renal denervation, but ambulatory reductions are much smaller. This disparity is assumed to have a ...

The dose requirement may increase. The clinical effect should be monitored. If appropriate, the serum concentration of the drug should be measured. Increased distribution volume and increased renal ...

Analysis of fecal and urinary samples revealed that sipeimine is predominantly excreted unchanged via renal elimination. Conclusion: The pharmacokinetics, tissue distribution, metabolism, and ...

Digoxin causes a prompt and considerable water and salt diuresis in congestive heart failure. This may occur with little or no change in renal hemodynamics, but usually is associated with decreased ...

This may be counterintuitive, as it seems clear that GLP-1 drugs have overwhelmingly positive effects on kidney function. The latest data suggests that, in patients with type 2 diabetes and ...