In mouse kidneys, after the deletion of UT-A1 and UT-A3 genes, urine nitrogen excretion ... in the kidney, studies have shown that uremia patients have reduced Treg cells numbers and impaired function ...

We extend our discussion to encompass other indications for calcimimetics—secondary hyperparathyroidism in predialysis chronic kidney disease ... optimal usage of this drug.

This article reviews the current use of rituximab in renal disease and transplantation, and includes discussion of the drug's potential role in novel therapeutic protocols. Rituximab, a monoclonal ...

Renal hypoplasia, defined as abnormally small kidneys with normal morphology and reduced nephron number, is a common cause of pediatric renal failure and adult-onset disease. Genetic studies ...

Urinary sampling methods are summarised in table 2. The urine output must be collected over a prolonged (prespecified) period to measure cumulative drug (or metabolite) excretion per unit time, but ...

During the course of her therapy, she developed renal tubular acidosis despite being immunocompetent with no known renal ... investigation results, drawing original diagrams and algorithms, and ...

Novo Nordisk has abandoned a drug it licensed from KBP Biosciences last year in a deal valued at up to $1.3 billion after it missed the mark in a chronic kidney disease (CKD) trial. The Danish ...

Novo Nordisk has announced plans to move its ziltivekimab into phase 3 clinical development in atherosclerosis with chronic kidney disease ... cholesterol-lowering drugs and extra medications ...

Introduction: Chronic kidney disease (CKD) is a chronic progressive disease characterized by abnormalities in kidney structure or function caused by variousfactors. It has become a significant public ...

[11] Because the elderly are more vulnerable to drug-induced AKI and usually have poor renal recovery, [14,15] AKI during anti-TB treatment may be more common and serious in Taiwan, where more ...

has cleared its Investigational New Drug application (IND) to initiate a clinical study of the company’s investigational UKidney™ derived from a 10 gene-edited source pig. The study will enroll an ...

Urinary protein excretion (measured by UPCR from a 24-hour urine collection and/or spot UPCR ... Efficacy analyses were done in a modified intention-to-treat population consisting of all randomised ...