I have reviewed the manuscript "Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast" with interest. The described findings are relevant and useful for daily ...

Cancer cells migrate to the bone surface from the circulation, and once there, increase the production of RANKL, which promotes bone resorption by osteoclasts. Bone destruction results in release ...

A molecular signalling pathway called RANK–RANKL drives the expansion of the layer that lines the inside of the intestine during pregnancy and lactation. This tissue remodelling process has a ...

Role of RANKL in differentiation, fusion, activation and survival of osteoclasts. Osteoclast differentiation is a multistep process. Myeloid progenitor cells progressively differentiate into ...

Selumetinib also inhibited the activation of RANKL-induced NF-κB and MAPK signaling pathways in BMMs, thereby interfering with the expression of osteoclast marker genes. In the DMM-induced OA model, a ...

RANKL, secreted by osteoblasts, osteocytes, hypertrophying chondrocytes, and bone marrow stromal cells, stimulates the responsive RANK-bearing osteoclast precursors, to differentiate into active ...

Figure. Bone resorption in the skeleton often coexists with bone formation in the vasculature. A, Binding of RANKL to RANK stimulates osteoclast maturation and destruction of bone through loss of ...