The StrataQuest software was coupled with TissueFAXS, offering a convenient workflow that could automatically acquire up to ...

Denosumab works by specifically targeting the RANK ligand (RANKL), a critical protein in the life cycle of osteoclasts, the cells that break down bone. Denosumab's ability to inhibit RANKL makes it ...

Telecommunications Consultants India (TCIL), a major stakeholder in Bharti Hexacom, has asked the company to begin a new process for selling its infrastructure business to Indus Towers. In response, ...

Denosumab works by specifically targeting the RANK ligand (RANKL), a critical protein in the lifecycle of osteoclasts, the cells that break down bone. This study enrolled a total of 204 healthy ...

The company tested the drug on 204 healthy volunteers, comparing it with Prolia — the original version sold in Europe and the United States. The drug works by blocking a protein called RANKL, which is ...

The cells were maintained for further 3 weeks under osteogenic conditions to allow mineral deposition on the substrate. Predifferentiated osteoclasts (cultured for 7 days with M-CSF, followed by 6 ...

Department of Hygiene Toxicology, School of Public Health, Zunyi Medical University, Zunyi, Guizhou 563000, China Key Laboratory of Maternal and Child Health and Exposure Science, Guizhou Provincial ...

Additionally, following treatment with CagriSema, cagrilintide activates both amylin and calcitonin receptors, potentially reducing osteoclast activity and bone resorption, which might enhance BMD.

It has been found that anti-osteoporotic drugs (e.g., bisphosphonates) not only directly inhibit osteoclast activity, but also indirectly affect bone metabolism by modulating GM. For example, an ...

Reducing circulating estrogen levels increases osteoclast activity and, therefore, bone loss. 9 Not only is the balance of osteoblasts and osteoclasts altered, but the microenvironment of the ...