Receptor activator of nuclear factor-κB (RANK) is activated by its ligand, RANKL, an essential molecule for osteoclast development: in the absence of RANKL or RANK, osteoclast differentiation ...

The interaction of RANK and RANKL initiates a signaling and gene expression cascade that results in differentiation and maturation of osteoclast precursor cells to active osteoclasts capable of ...

The Discovery of New Members of the TNF Receptor and Ligand Families and Their Relationship to Osteoclasts and Bone Metabolism Binding of RANKL to RANK initiates a signaling cascade, which ...

For RNA-seq, 1×10 6 cells from day 0 were cultured in 1 mL/well osteoclast medium with 20 ng/mL M-CSF and 20 ng/mL RANKL in 24-well plates at 37°C and 5.5% CO 2. On day 2 of culture, 18 hours after ...

The osteoclast is a bone-resorbing cell with an origin in the monocyte-macrophage lineage (Yavropoulou and Yovos, 2008). As expected, MYC is involved in bone remodelling and is regulated by different ...

In brief, the differentiation fate regulation of BMSCs presents a complex network. Cross-Talk Between Bone and Fat Bone growth is the coupling of bone formation by osteoblasts and bone absorption by ...