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Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.

Myelin regeneration (remyelination) in the CNS depends on the recruitment, proliferation and differentiation of oligodendrocyte precursor cells (OPCs) at demyelinated lesions. However, despite the ...

Nuclear receptors regulate transcription in response to ligand signals and enable the pharmacological control of gene expression. However, many nuclear receptors are still poorly explored and are not ...

Get Instant Summarized Text (Gist) A machine learning method, Mal-ID, effectively diagnoses multiple diseases using B cell and T cell receptor sequences. It accurately distinguishes between ...

1 Center for Clinical Pharmacology, Washington University School of Medicine in Saint Louis and University of Health Sciences and Pharmacy in Saint Louis, St. Louis, MO, United States 2 Department of ...

Apart from CCR5 polymorphisms, most of the genetic correlates of the extreme protective phenotypes described here (LTNP, EC/HIC) are concentrated in the HLA locus and nearby. This underscores the ...

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor that regulates intestinal inflammation. PPARγ is highly expressed in the colon and can be activated by various dietary ...