Figure 3: In vivo delivery of siRNA with targeted exosomes results in brain-specific gene knockdown. To further investigate the brain targeting of RVG exosomes, transverse cortical sections from ...

Secreted RVG- exosome-delivered siRNA down-regulates opioid ... that MOR is down-regulated by IV injection of MV-RNAi in vivo. The down-regulation of MOR significantly abolishes morphine relapse.

The RVG-exosome-delivered RNAi against opioid receptor ... that MOR is down-regulated by IV injection of MV-RNAi in vivo. The down-regulation of MOR significantly abolishes morphine relapse.

The RVG-exosome-delivered RNAi against opioid receptor ... that MOR is down-regulated by IV injection of MV-RNAi in vivo. The down-regulation of MOR significantly abolishes morphine relapse.

The RVG-exosome-delivered RNAi against opioid receptor ... that MOR is down-regulated by IV injection of MV-RNAi in vivo. The down-regulation of MOR significantly abolishes morphine relapse.

(Nasdaq: CDAK), a clinical-stage biopharmaceutical company focused on pioneering the development of exosome-based therapeutics as a new class of medicines, today announced new preclinical data ...

“The data demonstrated functional RNA expression in vivo further showing the power of our exosome platform to potentially expand into areas beyond SARS-CoV-2. This strengthens my belief that our ...

The data from exoIL-12 in vivo preclinical studies highlight the unique potential of engEx exosomes to direct and retain IL-12 pharmacology at the tumor injection site, driving significantly ...

In addition, efficient methods for delivering siRNAs to bacteria in vivo are not currently available. In this study, the authors demonstrated that exosomes can serve as delivery vehicles to ...

This class of therapeutic agents suffers from high sensitivity to enzymatic degradation, poor cellular uptake and rapid renal and liver clearance, limiting their in vivo applications. Delivery of ...

In vitro and in vivo data were presented covering multiple aspects of exosome engineering including identification of new proprietary protein scaffolds for improved drug loading, engineered ...