The following is a simplified summary of the catalysis and regulation of RNA splicing. RNA splicing is essential for processing pre-mRNA transcribed from the more than 90% of human protein-coding ...

癌症治疗领域迎来重磅发现！科学家们锁定了一种意想不到的"肿瘤身份证"——由RNA剪接错误（mis-splicing）产生的新抗原（neoantigen）。在剪接因子突变的髓系恶性肿瘤中，这些异常拼接的蛋白质片段就像癌细胞特有的"分子条形码"，为精准免疫治疗提供了理想靶点。

RNA 剪接并非单一、孤立的事件，它既可以在转录的同时发生，即共转录剪接（co - transcriptional splicing），也能在转录结束后进行，也就是转录后剪接（post - transcriptional splicing）。近年来，随着科研技术的飞速发展，科学家们以史无前例的时空分辨率对 RNA 剪接 ...

Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences ...

RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding regions ...

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Gliomas, a type of brain tumor, are notoriously difficult to treat due to their complex genetic makeup and ability to evade ...

RNA splicing ribozymes have been shown to possess a conserved active site that can engage small molecules, opening possibilities for the control of gene expression.

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.