This manuscript describes an important finding of the transcriptional control of a chimeric gene transfer agents (GTA) cluster in Bartonella by a processive anti-termination factor (BrrG). The ...

Copy number variants (CNVs) arise by homologous recombination (HR) between repeated sequences (recurrent CNVs) or by non-homologous recombination mechanisms that occur throughout the genome (non ...

Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin–angiotensin system (RAS) is involved in the regulation of ...

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead ...

Graphical Abstract. Hypothetical mechanisms of mitophagy dysfunction in POLG-mutant astrocytes. Nicotinamide riboside was provided by Evandro Fei Fang (University of Oslo, Norway). The cells were ...

However, recent studies have identified molecular mediators of morphologically necrotic cell death, including PARP (poly-ADP-ribose polymerase), and the kinase RIP (receptor interacting protein ...