RNA interference-mediated depletion of MMB subunits LIN9 and B-MYB, and ChIP experiments in the human lung adenocarcinoma cell line H23 confirmed that MMB is required to drive overexpression of ...

Expression of c-Myb is required for normal hematopoiesis and for proliferation of myeloid leukemia blasts and a subset of T-cell leukemia, but its role in B-cell leukemogenesis is unknown. We ...

RNA interference, or RNAi, is a form of gene regulation. Once genes are transcribed into RNA and spliced into a mature messenger RNA, they are normally translated into proteins. If a second RNA can… ...

Rgenta Therapeutics Inc. has presented their work on the discovery and development of RGT-61159, a potential first-in-class oral inhibitor of the oncogenic transcription factor c-MYB. RGT-61159, an ...

RNA interference also works in other worms, plants, fruit flies, and, to some extent, zebrafish, a vertebrate. No one had extended the technique to mammals, however, and some scientists thought ...

First-in-human Phase 1a/1b clinical trial will evaluate orally available, RGT-61159 designed to selectively target MYB RNA and inhibit oncogenic MYB protein production Preclinical data supporting ...

First-in-human Phase 1a/1b clinical trial will evaluate orally available, RGT-61159 designed to selectively target MYB RNA and inhibit oncogenic MYB protein production Preclinical data supporting ...

Orally available RGT-61159 demonstrates potent inhibition of MYB synthesis and significant anti-tumor activity in a range of xenograft models of adenoid cystic carcinoma (ACC) Data support planned ...

Orally available RGT-61159 demonstrates potent inhibition of MYB synthesis and significant anti-tumor activity in a range of xenograft models of adenoid cystic carcinoma (ACC) Data support planned ...