Verastem shows strong late-stage pipeline progress, financial discipline, and a diverse portfolio that support long-term ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase (MEK)/extracellular signal-regulated kinase (ERK) cascade is commonly observed in cancer cells, leading to malignant cell proliferation, cell ...

Background: SPYK04 is a novel MEK1/2 inhibitor designed to enhance RAF-MEK binding and potentially inhibit feedback activation of MEK1/2. This approach was developed to address the limited efficacy of ...

MAPK activation increased in the rat hippocampus after an associative learning task, contextual fear conditioning. ... Pax6 affects Ras-Raf-ERK1/2 in mouse aging brain ...

Nat Clin Pract Endocrinol Metab. 2006;2(4):180-181. The fact that PTC is associated with mutually exclusive alterations to MAPK pathway effectors offers intriguing therapeutic opportunities. Ras ...

The Road Accident Fund (RAF) has been accused of deliberately withholding information from Parliament’s Standing Committee on Public Accounts (Scopa) about the top 10 law firms to receive briefs ...

Controversial Road Accident Fund (RAF) CEO Collins Letsoalo has been placed on special leave with full pay and benefits. This was disclosed by Deputy Minister of Transport Mkhuleko Hlengwa on ...

Collins Letsoalo, CEO of the Road Accident Fund, is placed on special leave as investigations into corruption allegations unfold, raising concerns about governance and accountability.

The RAF Board informed the Transport Department that Letsoalo will remain on leave until the conclusion of a Special Investigations Unit probe. Letsoalo is implicated in a R79 million lease tender ...

As of the cut-off date of April 2, 2025, a total of 21 patients had been enrolled and received at least one dose of PAS-004 in six cohorts (Capsules: 2mg, 4mg, 8mg, 15mg, 22mg / Tablets: 4mg). The ...

综述：黑米的生物活性成分、功能特性、健康益处及食品应用的综合评述 《Food Chemistry Advances》：Bioactive compounds, functional properties, health benefits, and food applications of black rice: a comprehensive review ...