Active caspase 1 causes pyroptosis and is responsible for proteolytic maturation of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Pyroptosis is characterized by caspase 1 ...

Pyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and ...

Pyroptosis, also known as cell inflammatory necrosis, is a new way of programmed cell death discovered and confirmed in recent years, which is characterized by dependence on inflammatory caspase and ...

1 Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China 2 Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing ...

Pyroptosis is a morphologically and mechanistically distinct form of cell death and is characterized by GSDMD (gasdermin D) or GSDME (gasdermin E)-mediated necrosis with excessive inflammatory factor ...

Upon CARD8 activation, caspase‐1 cleaves its pore‐forming substrate GSDMD which executes pyroptosis. Inflammasomes function as cytosolic sensors of microbial infection as well as perturbation of ...

Why does pyroptosis take place? Pyroptosis is a form of programmed cell death that occurs during intracellular pathogen infection, as part of the body's antimicrobial response. Cell-surface ...