This study aimed to investigate the role of NLRP3/caspase-1/gasdermin D (GSDMD)-mediated pyroptosis in hyperoxia-induced lung injury in neonatal mice and to evaluate the potential protective effects ...

Emerging evidence implicates intestinal epithelial cells (IECs) pyroptosis as a key contributor to IBD progression. Bone marrow mesenchymal stem cell exosomes (BMSCs-Exo) exhibit anti-inflammatory and ...

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Contributed by Jonathan L. Sessler; received August 23, 2023; accepted January 16, 2024; reviewed by Ling Huang and Guo Li ...

Purpose: Diabetic retinopathy is currently considered a chronic inflammatory disease involving NOD-like receptor family pyrin domain containing 3 inflammasome activation and retinal microglial ...

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China ...

近日，东南大学智能材料研究院院长、首席科学家、化学化工学院李全团队在肿瘤光诊疗领域取得突破性进展，开发出一种新型基于近红外二区的J-聚集体纳米药物，为克服现有纳米药物在肿瘤治疗中的局限性提供了创新解决方案。相关成果以“In Situ ...

Necrosis can occur accidentally or can be induced by tightly regulated pathways. Over the past decades, different forms of regulated necrosis, including necroptosis, ferroptosis, pyroptosis, and ...

Cell death plays a pivotal role in various physiological and pathological processes. However, distinguishing between different cell death modes such as apoptosis and pyroptosis based on brightfield ...