Emerging evidence implicates intestinal epithelial cells (IECs) pyroptosis as a key contributor to IBD progression. Bone marrow mesenchymal stem cell exosomes (BMSCs-Exo) exhibit anti-inflammatory and ...

During cell-to-cell spread, HIV-1 protease activity triggers CARD8 inflammasome activation and IL-1β release from macrophages, which may contribute to inflammation and chronic immune activation.

Among these DEGs, 45 PRDEGs were identified, suggesting the potential involvement of pyroptosis in the pathological processes of CA. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes ...

State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China ...

近日，东南大学智能材料研究院院长、首席科学家、化学化工学院李全团队在肿瘤光诊疗领域取得突破性进展，开发出一种新型基于近红外二区的J-聚集体纳米药物，为克服现有纳米药物在肿瘤治疗中的局限性提供了创新解决方案。相关成果以“In Situ ...

传统观点认为，延胡索酸衍生物抑制CD8+ T细胞的功能，其天然代谢物的调控功能与机制则不清楚。延胡索酸对CD8+ T细胞的研究进展得益于近期江鹏实验室的工作。肿瘤微环境中的延胡索酸可直接抑制CD8+ T细胞的TCR ...

尽管已知神经炎症在SAE发病中起关键作用，但具体分子机制尚不清楚。小胶质细胞作为中枢神经系统的主要免疫细胞，其过度激活导致的焦亡(pyroptosis)被认为是SAE神经损伤的核心环节。然而，调控小胶质细胞焦亡的关键分子开关仍有待阐明。 武汉大学的研究团队 ...