Uric acid is a natural waste product that the body produces after breaking down purines, which is found in certain foods and ...

本研究针对结核病治疗中耐药性及疗程长的核心难题，通过表型筛选发现靶向PurF（嘌呤从头合成关键酶）的小分子抑制剂JNJ-6640。该化合物对临床分离株展现纳摩尔级杀菌活性（MIC90=8.6±3.9 nM），通过CRISPRi基因敲降和稳定同位素标记证实其特异性抑制PurF，并证明 ...

Uric acid issues are far more common than most people realise, but the fix could be as simple as what's on your plate. A ...

For the unversed, uric acid is a waste product formed when the body breaks down purines, which are found in foods like red meat, seafood, and alcohol. The kidneys filter and remove uric acid through ...

The Bhujangasana opens up your chest and stimulates your abdominal organs, aiding in detoxification and reducing inflammation ...

Conclusion Oxidative stress, especially through purine metabolism pathway, is a major metabolic event during reperfusion and may contribute to the ischaemia reperfusion injury of lung grafts. Data are ...

Parkinson’s disease is a neurodegenerative condition that affects an individual’s brain, causing issues with their movement, sleep and mental health. Common symptoms include tremors, slowed ...

Summary: A new study has revealed critical metabolic impairments in Parkinson’s disease (PD), focusing on purine metabolism and ATP recycling. Researchers found that patients with PD have ...

By analyzing the blood and cerebrospinal fluid (CSF) of the patients, researchers have discovered critical impairments in purine metabolism and the recycling of adenosine triphosphate (ATP ...