Uric acid is a natural waste product that the body produces after breaking down purines, which is found in certain foods and ...

本研究针对结核病治疗中耐药性及疗程长的核心难题，通过表型筛选发现靶向PurF（嘌呤从头合成关键酶）的小分子抑制剂JNJ-6640。该化合物对临床分离株展现纳摩尔级杀菌活性（MIC90=8.6±3.9 nM），通过CRISPRi基因敲降和稳定同位素标记证实其特异性抑制PurF，并证明 ...

Uric acid issues are far more common than most people realise, but the fix could be as simple as what's on your plate. A ...

Large-scale metabolomic analyses of pan-cancer cell line panels have provided significant insights into the relationships between metabolism and cancer cell biology. Here, we took a pathway-centric ...

It is likely because Put is polycationic, meaning it can bind and stabilize osmotic micromolecules (Qu et al., 2020). Sucrose metabolism is often used as an indicator of environmental stress and plant ...

For the unversed, uric acid is a waste product formed when the body breaks down purines, which are found in foods like red meat, seafood, and alcohol. The kidneys filter and remove uric acid through ...

The Bhujangasana opens up your chest and stimulates your abdominal organs, aiding in detoxification and reducing inflammation ...

† Department of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, Colorado 80523, United States, ‡ Life Sciences Institute and Department of Medicinal Chemistry, The University ...

Here, we demonstrate an enzymatic approach based on the purine metabolism process that yields significant quantities of guanine crystals in aqueous solution at neutral pH. Significantly, this mirrors ...

The study revealed significant associations between microbial pathways related to L-arginine biosynthesis and butyrate production with higher BMD. L-arginine is an amino acid that is essential for ...