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颠覆传统!反向疫苗学如何让家禽疫苗研发快人一步?
针对鸡白痢,研究人员基于沙门氏菌 Pullorum 菌株 R51 的基因组,筛选出 22 种潜在疫苗候选蛋白,其中 PstS 等蛋白能引发免疫反应,PstS 的保护效果显著,使鸡的存活率达到 75%,远高于对照组的 31.25% 。 为了更全面地寻找潜在疫苗抗原,泛基因组反向疫苗学方法在 ...
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