Prox1 Is Required for Granule Cell Maturation and Intermediate Progenitor Maintenance During Brain Neurogenesis. PLoS Biology , 2010; DOI: 10.1371/journal.pbio.1000460 Cite This Page : ...

Prox1+ cells (pink) make up the arachnoid’s inner layer. Dural fibroblasts (aqua) lie above the arachnoid, embedded in a collagen matrix (dots). [Courtesy of Pietilä et al., Neuron, 2023.] ...

As PROX1 expression decreased, the tumor cells died. The impact was similar to when the team genetically removed PROX1 from the cells. "Our work implicates PROX1 as an important early driver away ...

They identified the gene PROX1, which plays a role in dictating cell identity in both normal cells and cancer cells. The team found that as prostate cancer cells transition to an alternate identity, ...

Early driver of prostate cancer aggressiveness Study links higher expression of the gene PROX1 to aggressive change in prostate tumor cells; FDA-approved class of drugs can disable PROX1 ...

Prox1 is essential for differentiation of skeletal muscle stem cells called satellite cells. During differentiation satellite cells form long, multinuclear myotubes, but if they lack Prox1 gene ...

PROX1 modulation influenced the behavior of specific CRC cells, with its overexpression fostering invasiveness. Kaplan-Meier evaluations demonstrated a link between PROX1 or α-SMA and survival ...

A guardian molecule ensures that liver cells do not lose their identity. This has been discovered by researchers from the German Cancer Research Center (DKFZ), the Hector Institute für ...

"Despite many previous investigations into the function of adult-born dentate granule cells, their contribution to population activity patterns in behaving animals has remained elusive," Stephen B ...

The impact was similar to when the team genetically removed PROX1 from the cells. "Our work implicates PROX1 as an important early driver away from androgen receptor dependence.