Tobacco-based products, including e-cigarettes, have gained popularity as perceived safer alternatives to traditional smoking despite their addictive nature. However, emerging evidence shows that ...

Key treatments for Alzheimer’s, rare cancers, and infectious diseases are under review, with new vaccines and therapies like ...

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

NU-9 targets a shared underlying mechanism found in various neurodegenerative diseases. A new study from Northwestern ...

In animal models, NU-9 was found to show promise in treating Alzheimer's by reducing toxic protein buildup and brain ...

Python support for Azure Functions is based on Python 3.8, 3.9, 3.10, 3.11, and 3.12 serverless hosting on Linux, and the Functions 2.x (EOL), 3.x (EOL) and 4.0 runtime. This project welcomes ...

The punitive move comes amid the Trump administration’s pressure campaign against big law firms. By Devlin Barrett Reporting from Washington The Justice Department on Wednesday barred its ...

But how well upper motor neurons function in mice is similar to how well they function in humans ... "Cells have two important 'junk compartments': the lysosome and the proteasome," Silverman said.

Knockdown of p62 disrupts the formation of these ADPr condensates. Importantly, these structures are unaffected by autophagy inhibition, but depend on ubiquitination and proteasome activity. Taken ...

A new study finds that proteasomes—structures that reside in all cells in the body and typically break down damaged proteins—can produce peptides that attack bacterial infections. When ...

Bacterial levels surged. But when the proteasome was allowed to function normally, the cells secreted small peptides that stunted bacterial growth. The effect vanished when these peptides were ...