The prolyl isomerase PIN1 has been identified as a ... Protein phosphorylation is a key cellular signalling mechanism that induces changes in protein conformation 1,2. For example, the ...

Figure 1: Pin1 interacts with activated p53 in a phosphorylation-dependent manner. To identify the Pin1 binding sites on p53, we generated the corresponding Ser/Thr to Ala point mutants, and ...

They had a homozygous start-codon mutation in the peptidyl-prolyl isomerase B gene (PPIB), which results in a lack of cyclophilin B (CyPB), the third component of the complex. The proband's ...

The immunosuppression and anti-isomerase activity turned out to be distinct, raising the possibility that only the latter was the basis for neuroprotection. However, the peptidyl-prolyl isomerase(s) ...

The conformational change is catalyzed by the prolyl isomerase Pin1, which may also prevent neurofibrillary tangles by isomerizing a proline residue in the microtubule binding protein tau (see ARF ...

ZHAO Guoping from High Magnetic Field Laboratory, Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) proposed a mechanism by which protein disulfide isomerase (PDI ...

FG-4592 is a novel, first-in-class hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) that works through stabilization of HIF, a mechanism distinct from that of current anemia ...

Isomerase is a world leader in the discovery and development of molecules that target peptidyl-prolyl isomerases such as cyclophilins. The team is actively involved in the pharmacology ...