Oncogene - MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion Skip to main content Thank you for visiting nature.com.

MMP-9 expression was lower in co-treated MCF-7 cells relative to dandelion extract-treated cells. However, in MDA-MB-231 cells, MMP-9 expression did not significantly differ across treatment groups.

High T/N MMP-9 RNA expression was associated with a significantly shorter disease-free (P = .0001) and overall (P = .0002) survival duration. In univariate and multivariate analyses, T/N MMP-9 RNA ...

MMP-2 expression was measured by reverse transcription polymerase chain reaction (RT-PCR) and Western blot. Cell proliferation, apoptosis were examined by MTT, flow cytometry, respectively.

The firm’s pipeline comprises two preclinical-stage antibodies, the MMP-9-targeting CALY-001, and CALY-002, a humanized mAb targeting IL-15, which Calypso acquired from iDD biotech in 2013.

These cells are normally quiescent in health blood vessels but their proliferation rate can be dramatically increase in response to vessel injury or insult, where it promotes neointima formation after ...