Jarkko Rautio of the School of Pharmacy at University of Eastern Finland demonstrates the versatility of prodrugs strategies in medicinal chemistry to overcome various ADMET barriers (absorption, ...

Anticancer drugs could be generated at tumors by the reaction of a prodrug with a gold catalyst in a protein scaffold 1. Chang, T.-C., Vong, K., Yamamoto, T. & Tanaka, K. Prodrug activation by gold ...

Zhu Guangyu, Associate Professor of Department of Chemistry, City University of Hong Kong (CityU) and his research team have recently developed phorbiplatin, an anti-cancer prodrug that can be ...

The prodrug strategy is basically a smart key that has been designed specifically to unlock the door to cancer treatment only when it reaches the correct target. Utilizing this prodrug strategy ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status ...

Citation: Researchers design 'prodrug' that targets cancer cells' big appetite for glutamine, leaving healthy cells unharmed (2022, November 16) retrieved 24 May 2025 from https://medicalxpress ...

Researchers design 'prodrug' that targets cancer cells' big appetite for glutamine, leaving healthy cells unharmed Augmented drug eliminates cancer cells without causing toxicity ...

Similarly to E, the main toxicity of the prodrug EP is dose-dependent leukoneutropenia, which is dose-limiting at the oral MTD of 150 mg/m2/d for 5 days. The recommended oral dose of EP is 125 mg/m2/d ...

Askgene Pharma Inc. has received FDA clearance of its IND application to start a phase I study of ASKG-915, a novel and proprietary anti-PD-1/IL-15 prodrug fusion molecule for the treatment of cancer.