Examples of the most frequently studied applications are listed in sub-sections below. It is to be noted, however, that possible prodrug applications are not restricted to those listed.

Jarkko Rautio of the School of Pharmacy at University of Eastern Finland demonstrates the versatility of prodrugs strategies in medicinal chemistry to overcome various ADMET barriers (absorption, ...

Utilizing this prodrug strategy, we have synthesized the novel prodrug TTFA-Platin, which combines two powerful drugs: TTFA (which targets mitochondria, which is the powerhouse of the cell) with ...

An investigational viral immunotherapy (CAN-2409; aglatimagene besadenovec) combined with a prodrug improved disease-free survival (DFS) when added to standard curative-intent radiotherapy for newly ...

Citation: Researchers design 'prodrug' that targets cancer cells' big appetite for glutamine, leaving healthy cells unharmed (2022, November 16) retrieved 24 May 2025 from https://medicalxpress ...

The Johns Hopkins-discovered prodrug, called DRP-104 (sirpiglenastat), is in early-stage clinical trials in people with advanced solid tumors. The newly published studies in mice show that the ...

POSTECH professor Won Jong Kim’s research team develops self-immolative nitric oxide anti-cancer prodrug. The drug removes cancer cells in lymph nodes after being conjugated to proteins.

EB-373, Enveric’s lead product candidate, is a new chemical entity psilocin prodrug being developed for the treatment of anxiety disorder. The optimized, phase 1-ready formulation of EB-373 ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how branched glycopolymer prodrug-derived nanoassembly combined with a STING agonist activates an immuno-supportive status ...

The newly modified prodrug takes advantage of a common property of cancer cells: a voracious appetite for an amino acid called glutamine, which is a critical building block for proteins, lipids ...