Biphenyl hydrolase-like protein (BPHL, NCBI accession number NP_004323) is a novel human serine hydrolase recently identified as a human valacyclovirase, catalyzing the hydrolytic activation of the ...

An investigational viral immunotherapy (CAN-2409; aglatimagene besadenovec) combined with a prodrug improved disease-free survival (DFS) when added to standard curative-intent radiotherapy for newly ...

Examples of the most frequently studied applications are listed in sub-sections below. It is to be noted, however, that possible prodrug applications are not restricted to those listed.

Prodrug-based bispecific antibodies for cancer therapy: advances and future directions. ... Another example is Prot-FOLR1-TCB, a protease-activated anti-folate receptor 1 TCB, equipped with an ...

For example, Duan et al. developed a prodrug-based nanomedicine of PEGylated multistimuli-responsive dendritic copolymer coupled with DOX . The dendritic polymers mainly consisted of poly ...

Elysium Therapeutics today announced positive results from a Phase 1, human-proof-of-concept study (O2P-001) investigating the company's proprietary Oral Overdose Protected (O2P™) hydrocodone prodrug ...

Most Chinese herbal medicines are poor aqueous solubility, low bioavailability and stability, and non-target specificity, limiting their clinical applications. The above resveratrol prodrug examples ...

By comparison, previous studies which focused solely on bacterial resistance to the parent form of antibiotics yielded parameters that may not apply to prodrug forms. For example, the minimum ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Analyses of potential prodrug failure ...

For example, liver-targeted prodrug delivery was achieved by harnessing the distinct substrate specificity of the liver-specific isoform of P450, CYP3A4 (Erion et al., 2005; Erion et al., 2004).