The sensitivity and comprehensive phosphorylation site mapping of this approach was demonstrated by using two standard phosphoprotein samples of α-casein and β-casein, and this approach was further ...

Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the ...

MIT researchers found that high-fat diets cause metabolic enzyme dysfunction and insulin resistance by increasing reactive oxygen species in cells. However, antioxidants reversed much of the damage in ...

Protein phosphorylation is one of the most widespread regulatory mechanisms in eukaryotes. Over the past decade, phosphorylation site prediction has emerged as an important problem in the field of ...

Traditionally, the study of single protein phosphorylation has relied on Western blot profiling with site-specific antibodies directed against known phosphorylation sites. Such an approach loses ...

Phosphorylation sites reduce the likelihood of amyloidogenic contacts locally. Amyloidogenicity profiles for (A) unmodified human FUS PLD, and (B) fully phosphorylated FUS PLD sequences. The ZipperDB ...

Phosphorylation sites include a majority of serines (59%), followed by 37% threonines and some tyrosines (4%). Further compilation of the reported LRRK2 phosphosites indicates that 37 are reported by ...

Protein phosphorylation is an important type of post-translational modification that regulates various activities of cell life inside human body. The accurate identification of phosphorylation sites ...

The specificity of protein kinases for cMyBP-C phosphorylation sites is indicated by black arrows. Inhibitory and activating effects of individual phosphorylation sites on thin and thick filament ...

A comprehensive analysis of the human SUMO proteome, in HeLa and U2OS cell lines and under different conditions, identifies new SUMOylated sites and reveals cross-talk between SUMO and other post ...