Compared with large scale phosphorylation analysis at the proteome level, comprehensive and reliable phosphorylation site mapping of individual phosphoprotein is equally important. Here, we present a ...

at ER–PM Contact Sites (CS). Here, we addressed the fate of the incoming DAG in the ER. We show that diacylglycerol kinases (DGKs) DGK1 and DGK2 form a module with SYT1 functionally coupling DAG ...

Growth factors act on individual cells within tissues to signal a variety of cellular processes including proliferation, differentiation, migration, fate, survival or apoptosis. Many cell types ...

The neural substrate for “sleepiness,” as well as the molecular mechanisms determining daily sleep amounts, remain mysterious. Here, we found that a single amino acid, S551, of the protein kinase SIK3 ...

Erythritol may impair cellular functions essential to maintaining brain blood vessel health, according to researchers at the ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium ...

Professor Sun Jinpeng's team and Professor Yu Xiao's team at Shandong University, collaborating with Professor Jiang Changtao from Peking University, Professor Pang Yanli, and Professor Ji Linong, ...

Scientists at the Broad Institute of MIT and Harvard have identified 4,208 previously unannotated open reading frames (ORFs) across 679 human-associated viral genomes using a high-throughput method ...

Newborn babies and patients with Alzheimer's disease share an unexpected biological trait: elevated levels of a well-known ...

The study sheds light on a crucial protein, PfPPM2, which controls asexual division and switching between the sexual forms in ...

Phase 2 study, led by Dr. Antonio Jimeno at the University of Colorado Anschutz Medical Campus will evaluate NT219 in ...