The authors provide solid in vitro evidence for the early events of daptomycin interaction with phospholipid headgroups and stronger, specific interaction with phosphatidylglycerol. This work will be ...

Daptomycin (Dap) is an acidic, cyclic lipopeptide composed of 13 amino acids, known for preferential binding to anionic lipids, particularly phosphatidylglycerol (PG), which are prevalent components ...

Modification of phosphatidylglycerol by the attachment of a lysine residue to the glycerol head group is an adaptive response that is used by pathogens to increase their resistance to cationic ...

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