For over a decade, scientists have debated the risks and benefits of so-called “gain of function” research. They’ve long tinkered with viruses and bacteria to endow them with new functions ...

The peptidyl-prolyl isomerase Pin1 has wide-ranging influences on the occurrence and development of neurological diseases. It has also been suggested that Pin1 acts on epileptic inhibition, and the ...

Find more information on the Altmetric Attention Score and how the score is calculated. The peptidyl transferase center (PTC) in the large subunit of the ribosome plays a critical role in protein ...

Ribosome assembly is an essential and conserved process that is regulated at each step by specific factors. Using cryo-electron microscopy (cryo-EM), we visualize the formation of the conserved ...

China The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.

Utilization of the translation machinery (TM) to incorporate unnatural amino acids (UAAs) to create polymers with novel function holds great promise for synthetic biology ... We show that the ribosome ...

We find that catalysis is at least 100‐fold slower with the dA76‐substituted peptidyl‐tRNA substrate and that the peptidyl transferase centre undergoes a slow inactivation when the peptidyl‐tRNA lacks ...

Here we report two structures of the 70S ribosome from Thermus thermophilus with a complete peptidyl transferase center including an A-site tRNA whose CCA tail and associated amino acid are ...