GUADALAJARA, Mexico — "Somatic reprogramming is a strategy in which we are not modifying a single part of the cell, but we are reprogramming a normal cell to transform it into a pacemaker cell ...

While each cell in isolation was not “the pacemaker cell”, the cell system generated rhythmic APs: The subthreshold signals of non-excitable cells were transformed into respective membrane potential ...

Biological pacemaker is a therapy for cardiac rhythm disease, which can be transformed from ventricular myocytes (VMs) by overexpressing HCN gene which codes the expression of ...

Each heartbeat is triggered by the sinoatrial node (SAN), the primary pacemaker of the heart. Studies in animal models have revealed that pacemaker cells share a common progenitor with the ...

In the study, reported on March 8, 2022, in Circulation Research, the researchers used an animal model as well as human stem cell-derived pacemaker cells to show that SARS-CoV-2 can readily infect ...

To study SARS-CoV-2’s effects on pacemaker cells in more detail and with human cells, the researchers showed that the induced human pacemaker cells express the receptor ACE2 and other factors ...

The SARS-CoV-2 virus can infect specialized pacemaker cells that maintain the heart's rhythmic beat, setting off a self-destruction process within the cells, according to a preclinical study. The ...

An important aspect of this study is that SAN pacemaker cells were susceptible to SARS-CoV-2 infection in vivo. Although there are several reports showing that in vitro cardiomyocytes, especially stem ...

In this study, using both a hamster model and human embryonic stem cell–SAN–like pacemaker cells, the impact of SARS-CoV-2 infection on the primary pacemaker cells of the heart was explored.

Implantable pacemaker. Most pacemakers pace the atria, or upper chambers of the heart. This is because, traditionally, the pacemaker cells start in the atria.