宫颈癌 (CC)仍是全球女性癌症死亡的主要原因，部分患者会出现原发性肿瘤早期转移，但其机制尚未阐明。研究发现E3泛素连接酶家族成员RING box蛋白-1 (RBX1)在90例CC患者活检组织中异常高表达，且在转移病例中表达更为显著。体外实验显示，在Hela细胞中过表达RBX1可显著增强细胞迁移和侵袭能力，而敲低RBX1则产生相反效果。机制研究表明，RBX1通过调控基质金属蛋白酶 ...

吞噬是生物体摄取、消化和吸收营养物质或病原体的关键过程，在人体免疫系统中扮演重要角色。吞噬与炎症的发生关系密切，当机体受损或感染时，吞噬细胞迅速迁移至炎症部位，吞噬病原体和受损组织，减轻炎症。同时，吞噬过程中释放的炎症介质，如细胞因子、趋化因子和活性 ...

The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role in cell growth and survival and is activated in various cancers. Multiple components of the pathway are frequently targeted by ...

肿瘤治疗电场（TTFields）已用于治疗多种癌症，但部分患者疗效不佳。为探究原因，研究人员开展 TTFields 与 PI3K/AKT 通路关系的研究。结果发现 PI3K/AKT 通路参与癌细胞对 TTFields 的反应，抑制该通路可增敏。这为提升 TTFields 疗效提供新思路。

A new review was published in , Volume 16, on March 13, 2025, titled "Signaling pathway dysregulation in breast cancer." ...

A groundbreaking study published in Research (2025, DOI: 10.34133/research.0545) has elucidated the molecular mechanisms by which protein phosphatase 2A (PP2A) regulates CD8+ T cell-mediated immune ...

Innovations in therapeutic strategies, coupled with a deeper understanding of breast cancer biology, will be essential for advancing personalized ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK ...

AUSTIN, TX & PHILADELPHIA, PA — Faeth Therapeutics and The GOG Foundation, Inc. have announced a significant milestone in the ...

A combination, triplet therapy that targets cancer cells from within and without caused tumors to shrink or stabilize in ...