A study reveals that lysozyme (LYZ) plays a pivotal role in age-related blood vessel inflammation by influencing gut bacteria ...

PI3K Inhibitors have emerged as a popular treatment for hormone-receptor-positive breast cancers, improving progression-free survival rates for those with ER+ breast cancer.

Oxidative stress is an imbalance of free radicals and antioxidants that can negatively affect your cells and tissues. Experts explain how to reduce it.

Initial OnKure Therapeutics, Inc. data from PIKture-01 study on OKI-219 for PI3Ka-H1047R breast cancer expected in Q4, 2024. Read more on OKUR stock prospects.

He and his colleagues hypothesized that combining paxalisib, a brain-penetrant PI3K/mTOR inhibitor, with RT might improve outcomes in patients with PI3K -mutant brain metastases.

By examining an Amgen med, a new Nature study offers better understanding of the mechanism behind PI3K-delta inhibitors' immune-mediated side effects.

Heart failure (HF) is a growing global health concern, affecting more than 64 million people worldwide. It develops when the heart can no longer pump enough blood to meet the body's demands, often due ...

Aspirin use in patients with PI3K-mutated colorectal cancer helped to reduce disease recurrence, highlighting the importance of upfront genomic testing.

These extra lipids help to protect the cells against oxidative stress, and therefore ferroptosis. Blocking PI3K-AKT-mTOR prevents this lipid synthesis and re-sensitizes the cells to ferroptosis.

The “unprecedented” observation raises a red flag for PI3K inhibitor approvals based on single-arm trials. In those studies, drug reviewers cannot properly evaluate the life extension marker ...