Department of Cardiology, Buddhist Tzu Chi General Hospital, Hualien 970, Taiwan School of Medicine, Tzu Chi University, Hualien 970, Taiwan Department of Physical Therapy, Graduate Institute of ...

Abstract:        Obesity, a growing global issue, has been closely associated with an increased risk of various cancers, especially breast cancer. El ...

Molecular Inflammation Research Center for Aging Intervention (MRCA), Pusan National University, Geumjeong-gu, Busan 609-735, Korea Research Center for Anti-Aging Technology Development, Pusan ...

The multi-billion deal, in which Eli Lilly will acquire Scorpion Therapeutics’ STX-478 program, is a shot in the arm for PI3K treatments, which have had a mixed history over the past few years.

The search for alternative treatments led to the finding that the phosphatidylinositol-3-kinase (PI3K) pathway that controls cell metabolism, growth, division, and survival and allows the cells to ...

We explored the therapeutic effect and underlying mechanism of PUE on cerebral I/R injury by inhibiting oxidative stress related to the PI3K/Akt/Nrf2 pathway in vitro and in vivo. Methods: The middle ...

Mechanistically, ELA-11 inhibited oxidative stress-induced apoptosis by suppressing mitochondrial membrane potential mediated by ERK/MAPK and PI3K/AKT signaling pathways. Moreover, ELA-11 acted as a ...

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that ... consequently protecting senescent cells from oxidative stress-induced ...