前列腺癌严重威胁男性健康，现有治疗手段存在局限。研究人员聚焦分支链氨基酸（BCAAs）及 BCAT2 在前列腺癌中的作用。发现 BCAT2 高表达与预后不良相关，其通过与 PCBP1 互作调节 PI3K/AKT 通路，影响细胞进程。该研究为前列腺癌诊疗提供新靶点和思路。

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance.

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is ...

Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. However, the pathological mechanisms and therapeutic strategies for ...

本研究针对非小细胞肺癌(NSCLC)奥希替尼耐药难题，揭示了METTL16通过m 6 A修饰调控miR-146b-5p稳定性，进而激活PI3K/AKT信号通路的 ...

1Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan. 2Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical ...

Within the core program, TFE3 fusions directly regulate genes involved in ferroptosis resistance and oxidative phosphorylation metabolism (OxPhos). Consequently, human tRCC tumors display high OxPhos ...

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China ...

Takeda shared positive TAK-279 phase 2b results for plaque psoriasis and initiated phase 3 trials in 2023. PI3K, AKT, and mTOR inhibitors – The survival blockers The PI3K/AKT/mTOR pathway is a ...