The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...
Jennifer Klomp and colleagues 7 used advanced mass-spectrometry techniques to map the ERK-dependent phosphoprotein ... do not sufficiently displace PI3K from active KRAS. In addition, active ...
The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to ...
The researchers treated the cells with varying concentrations of cordycepin and compared them to cells treated with known inhibitors of specific kinases in the MEK/ERK and PI3K/AKT/mTOR pathways.
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