The biological significance of activation of the PI3K-Akt and the Ras-ERK pathways in V-SEA-induced transformation was analysed in the V-SEA-RAT1 and V-SEA-3T3 cell lines by employing specific ...

Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the treatment landscape across subtypes.

The team found that resistance to this drug is associated with the hyperactivation of the cellular pathways PI3K/AKT and MEK/ERK and have explored the possibility of inhibiting these pathways as a ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

AEZS-136 is an integral part of the Company's kinase research program comprising the investigation of different compounds for single Erk inhibition, single PI3K inhibition and dual Erk/PI3K ...

Aberrant activation of the PI3K/AKT and MAPK/ERK KRAS-effector pathways occurs often in many types of cancers, and many therapeutic agents targeting components of these pathways have been developed.

Activated RAS chain reaction leads to ERK activation. *4 PI3K/AKT (AKT): This is a serine /threonine kinase associated with controlling various functions such as cell proliferation, metabolism ...

enabling simultaneous inhibition of the Raf-Mek-Erk and the PI3K-Akt signaling cascades. AEZS-136 was discovered using the Company's proprietary compound library and high throughput screening ...