BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

本研究针对宫颈癌治疗靶点匮乏的临床难题，揭示了间隙连接蛋白β5（GJB5）通过新型分子机制驱动肿瘤恶性进展的关键作用。研究人员通过多组学分析和功能实验证实，GJB5与Gαi3蛋白互作激活Akt-mTOR信号通路，显著促进宫颈癌细胞增殖、迁移并抑制凋亡。该发现为宫颈癌靶向治疗提供了全新分子靶点，相关成果发表于《Cell Death and Disease》。

A new AI-driven multimodal fusion system accurately predicts survival outcomes in patients with unresectable liver cancer ...

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, ...

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related deaths worldwide ...

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...