LY294002（AbMole，M1925）是一种经典的、不可逆的PI3K（磷脂酰肌醇3激酶）抑制剂，LY294002通过阻断PI3K/Akt/mTOR信号通路，调节细胞 ...

本研究针对结直肠癌(CRC)肝转移(LM)预后差、机制不明的临床难题，揭示了高转移性CT26-LM细胞通过分泌CXCL16激活Kupffer细胞(KCs)的 ...

2005; Xie and Bikle, 2007). Our present analysis aims to determine how E-cadh homophilic interaction contributes to PI3K/AKT activation in EOCs. We observed in two ovarian carcinoma cell lines ...

Collectively, these results further indicate that PAFR promotes malignancy of ESCC cells through the activation of PI3K/AKT pathway. PAFR-induced PI3K-AKT pathway activation correlates with the ...

本研究揭示了PI3K-Akt信号通路在新生儿肌腱再生中的核心调控机制。研究人员通过RNA测序和谱系追踪技术，发现PI3K-Akt通路通过促进Scx谱系腱细胞和Tppp3谱系腱鞘细胞的增殖、迁移及干性维持，驱动生理性肌腱再生。抑制该通路导致再生肌腱变薄、力学性能下降 ...

导读：PI3K/AKT信号通路在肿瘤发展中扮演着重要的角色。 9月28日，中山大学/苏州大学研究人员在期刊《Nature Communications》上 ...

BMPER attenuated PI3K/AKT signaling and suppressed BMP4-driven smooth muscle activation in models of PAH. BMPER overexpression mitigated the vascular remodeling that characterizes pulmonary arterial ...

Research Progress on Signaling Pathways of LGALS1 in Malignant Tumors. Journal of Biosciences and Medicines, 13, 142-155. doi: 10.4236/jbm.2025.136013 . Malignant tumors, commonly referred to as ...

Most patients with gastric cancer are diagnosed in advanced stages of the disease. Target identification and unveiling the molecular mechanisms behind it are crucial for this field.

AKT pathway activation is implicated in endocrine-therapy ... or another selective estrogen-receptor degrader or to AKT, PI3K, or mTOR inhibitors were excluded, as were patients with diabetes ...