The reason for this contradiction is not apparent from the current data but might be related to differences in the dependence of white muscle from different species on phosphagen versus anaerobic ...

Our findings reveal that, in normoxia, multiple enzyme systems maintain cells in a primed state ready to support increased glycolysis and HIF1α stabilisation upon oxygen limitation, until other ...

The rate-limiting enzymes of the glycolysis pathway are HK, PFK, and PKM (Figure 2). Changes in the activities of these enzymes play a key role in the pathogenesis of OC consequently, the enzymes can ...

Through genetic analyses, we uncovered roles for regulatory enzymes and mitochondrial localization in the cellular and subcellular dynamic regulation of glycolysis. Our study demonstrates the use of a ...

Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific pathogenesis of ...

Further investigation revealed that the downregulation of glycolysis seen in normal HBECs resulted from increased proteasomal degradation of phosphofructokinase (PFK), a rate-limiting enzyme in ...

They knew from their experiments that PFK, the limiting enzyme for glycolysis, is somehow removed after it's made if cells are grown on softer tissues. That finding caused the researchers to look ...